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Your collaborative, community-driven reference on psychoactive substances — their effects, risks, chemistry, history, cultural roles, and safe practices. | Your collaborative, community-driven reference on psychoactive substances — their effects, risks, chemistry, history, cultural roles, and safe practices. | ||
This wiki aims to combine accessible explanations with evidence-informed content, offering a balanced and responsible perspective on altered states of consciousness. | This wiki aims to combine accessible explanations with evidence-informed content, offering a balanced and responsible perspective on altered states of consciousness. | ||
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— DR. SAMUEL JOHNSON — | |||
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<li><strong>educational use</strong> — understanding mechanisms, effects, and contexts</li> | <li><strong>educational use</strong> — understanding mechanisms, effects, and contexts</li> | ||
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Latest revision as of 05:50, 26 November 2025
Welcome to PsychoactiveWiki
Your collaborative, community-driven reference on psychoactive substances — their effects, risks, chemistry, history, cultural roles, and safe practices. This wiki aims to combine accessible explanations with evidence-informed content, offering a balanced and responsible perspective on altered states of consciousness. Whether you are a researcher, clinician, harm-reduction advocate, or curious learner, PsychoactiveWiki provides a structured and growing foundation for understanding substances and the ways they interact with mind, body, and culture.
“He who makes a beast of himself gets rid of the pain of being a man”
— DR. SAMUEL JOHNSON —
⚠️ For Educational and Harm-Reduction Purposes Only
PsychoactiveWiki does not encourage, promote, or endorse the use of psychoactive substances under any circumstances. All content on this site is intended strictly for:
- educational use — understanding mechanisms, effects, and contexts
- harm reduction — minimizing risks where use occurs
- scientific, cultural, and historical documentation — preserving knowledge with accuracy and neutrality
Psychoactive substances carry genuine risks — physical, psychological, legal, and social. Effects vary greatly between individuals, contexts, and dosages. Individual physiology, mental health history, interactions, and environmental conditions all influence how substances act.
Always follow local laws. Always prioritize safety. Consult a licensed medical or mental-health professional when needed. This wiki does not give medical advice, cannot diagnose conditions, and is not a substitute for professional guidance.
If you are experiencing a medical or psychological emergency, contact local emergency services immediately.
Featured Article
Featured articles highlight a significant, well-documented, or historically important psychoactive substance. These entries showcase the level of depth, quality, and clarity we aim to maintain across the project. Featured articles may rotate to highlight new contributions, major updates, or noteworthy topics.
Template:Main page large image
Psilocybin
Psilocybin is a naturally occurring tryptamine psychedelic found in over 200 species of mushrooms. It is known for its visual phenomena, emotional amplification, introspection, and potential therapeutic applications. Used in spiritual, indigenous, and modern clinical contexts for centuries, psilocybin occupies an important role in the study of consciousness, neuroplasticity, and mental health interventions. Recent scientific interest has increased dramatically due to research into treatment-resistant depression, end-of-life anxiety, and addiction.
Community
Categories
Below are the major substance groups used on PsychoactiveWiki. Each category organizes pages by pharmacology, effects, and experiential characteristics, allowing readers to explore substances by shared mechanisms or subjective profiles.
- Psychedelics — Serotonergic and tryptamine-based mind-altering substances.
- Dissociatives — NMDA antagonists producing detachment, dreamlike states, and altered embodiment.
- Stimulants — Substances that increase alertness, energy, and sympathetic nervous activity.
- Depressants — Sedatives and CNS depressants affecting inhibition, coordination, and cognition.
- Empathogens — Compounds that enhance empathy, connection, and emotional softness.
- Research Chemicals — Novel or understudied substances with limited safety data.
- Natural Substances — Botanicals, fungi, and traditional psychoactives.
- Synthetic Substances — Laboratory-developed compounds across many classes.
Harm Reduction
Harm reduction is the central mission of this wiki. Every aspect of this project is structured around minimizing risk, increasing understanding, and promoting informed decision-making. The goal is to reduce harm—not to encourage use. Providing accurate information is one of the most effective ways to prevent injury, panic, and avoidable medical emergencies.
Users are encouraged to explore foundational harm-reduction topics:
- General harm reduction principles — A broad overview of safe practices.
- Set, Setting & Psychological Preparedness — How mindset and environment shape outcomes.
- Safe dosage practices — Understanding thresholds, variances, and substance-specific considerations.
- Dangerous combinations & interactions — Avoiding hazardous or lethal interactions.
- Recognizing and responding to medical emergencies — What to do when things go wrong.
These pages synthesize information from scientific literature, community reports, harm-reduction collectives, and public health resources.
Getting Started
Whether you're new to MediaWiki or new to psychoactive substance research, these resources will help you confidently explore, edit, and contribute to the project.
- How to edit pages — A beginner-friendly guide to editing markup, using templates, and structuring articles.
- List of psychoactive substances — Full alphabetical index for quick navigation and discovery.
- Templates and infoboxes — Standardized formatting tools for creating consistent, high-quality pages.
- All pages — Browse everything on the wiki, including lesser-known or newly created articles.
New Articles
- 01:15, 16 January 2026 Flubromazepam (hist | edit) [1,145 bytes] LSDream (talk | contribs) (Created page with "Flubromazepam is a long lasting psychoactive substance of the benzodiazepine class which produces anxiolytic, sedative, muscle relaxant, depressant and amnesic effects.[112][114] This compound was first synthesized in 1960, but was never marketed and did not receive any further attention or study until late 2012 when it appeared on the gray market as a novel designer drug.[112][114] It has potential use for short-term treatment of anxiety, insomnia, acute seizures, and t...")
- 02:00, 15 January 2026 Psychoactive Substances (hist | edit) [223 bytes] LSDream (talk | contribs) (Created page with "Psychoactive Substances are . . . List of psychoactive substances == Psychedelics == *DMT *LSD *Mescaline *Psilocybin Mushrooms == Depressants == === Benzodiazepines === * Flubromazepam")
- 01:22, 2 January 2026 Norbaeocystin (hist | edit) [649 bytes] LSDream (talk | contribs) (Created page with "- Also known as: C10H13N2O4P; 4-OPO4-T; 4-Phosphoryloxytryptamine; 1H-Indol-4-ol, 3-[2-aminoethyl] dihydrogen phosphate ester Norbaeocystin is a N-demethylated derivative of baeocystin (itself a N-demethylated derivative of psilocybin) that has been isolated from Psilocybe baeocystis grown in submerged cultures.[29] When dephosphorylated forms 4-hydroxytryptamine.[29] It is found as a minor compound in most psilocybin mushrooms.[29] It is not expected to contribute to...")
- 23:57, 23 December 2025 Serotonin (hist | edit) [7,513 bytes] LSDream (talk | contribs) (Created page with "Serotonin is a monoamine neurotransmitter. It is one of the key chemicals and hormones in the body and is affected by a large range of substances. Establishing a good understanding of how serotonin and its receptors function is key to understanding how psychoactive substances, along with a variety of other drugs, produce their effects. There is a wide variety of different substances that impact serotonin and its receptors: full/partial/inverse agonists, releasing agents,...")
- 15:14, 7 December 2025 Baeocystin (hist | edit) [1,573 bytes] LSDream (talk | contribs) (Created page with "Also known as: C<sub>11</sub>H<sub>15</sub>N<sub>2</sub>O<sub>4</sub>P; 1H-Indol-4-ol, 3-[2-(methylamino)-ethyl]dihydrogen phosphate ester thumb|300px Baeocystin is a zwitterionic alkaloid and monomethyl (N-demethylated) analog of psilocybin and a phosphorylated derivative of 4-HO-NMT (4-hydroxy-N-methyltryptamine).[59][61] It was first found in Psilocybe baeocystis and first synthesized by Troxler and his partners in 1959.[29][57][59] It i...")
- 04:05, 30 November 2025 Trip Sitter (hist | edit) [2,696 bytes] LSDream (talk | contribs) (Created page with "Is a term used by recreational and or spiritual drug users to refer to someone who remains sober to ensure the safety of the drug user.[71] I have personally only had a designated trip sitter(s) during my first trip. I was with a group of friends and 3 of us took mushrooms while 3 did not. Although, the 3 who did not not were in no means sober, they were people who I felt comfortable with and who made sure we were safe. I have personally been a trip sitter and do recomme...")
- 04:01, 30 November 2025 Bad Trip (hist | edit) [1,915 bytes] LSDream (talk | contribs) (Created page with "Bad trips (also known as a psychedelic crisis) are talked about a lot when discussing psychedelics, and to a lesser extent dissociatives and deliriants.[71] It is pretty much something everyone thinks, at one point, before taking a psychedelic substance: “I don’t want to have a bad trip”. But what exactly is a ‘bad trip’? It is generally a disturbing experience that can include serious negative effects, such as panic, paranoia, psychosis, feeling of impending d...")
- 03:55, 30 November 2025 Tripping Tips (hist | edit) [4,430 bytes] LSDream (talk | contribs) (Created page with "The best advice I can give once you start tripping is to “go with the flow”. It is extremely important that you try to relax and let things happen. This can be very difficult to do in some situations and in these cases it can be helpful to try and change environments, move around, or cuddle up and get comfy. I have had plenty of times when things get a little too intense or confusing and I've found that walking around and getting some fresh air always helps (granted...")
- 03:50, 30 November 2025 Set and Setting (hist | edit) [4,378 bytes] LSDream (talk | contribs) (Created page with "THERE IS NO GUARANTEE FOR A GREAT TRIP!! The experience will be different for everyone and unfortunately not all experiences are positive and some can even be dangerous. People seem to know that how much you take can impact your trip; however, equally as important are the environmental and psychological factors.[51] There are plenty of things that you can do to prepare your mind, body, and soul. The first step I always take is to research whatever compound I am taking....")
- 23:28, 29 November 2025 Psychedelic (hist | edit) [47,303 bytes] LSDream (talk | contribs) (Created page with "<center> ''“I know who I was when I got up this morning, but I must have been changed several times since then.”'' <br> - Lewis Caroll/Alice in Wonderland <div style="text-align:left;"> Psychedelics are a subclass of hallucinogens whose primary effect is to trigger non-ordinary mental states (also known as psychedelic experiences or “trips”). They are one of the most well known, well researched, and controversial groups of compounds. They have inspired interes...")
Disclaimer
PsychoactiveWiki exists to promote harm reduction, education, and responsible knowledge-sharing. This site does not encourage or normalize the use of psychoactive substances.
Information here is for:
- educational purposes
- scientific and cultural understanding
- safety awareness
- historical documentation
Always follow local laws. Always consult professionals when facing physical or psychological health concerns. This wiki assumes no responsibility for how information is interpreted or used.